Yes, you can use both a home SIM card and eSIM if you want. There’s nothing to stop you from doing so but there are things to consider.
If you want to use two SIM cards at once, regardless of what they are, you need a device which can support that. If you have an older model this may be inaccessible to you.
Once you have set both SIM cards up, you can choose which one you want to use for individual tasks.